Dermatophytes: role of host genetics in the development of illness

Abstract

Because dermatophytes and their hosts are so different, infection susceptibility is most likely the consequence of changes on both sides, as well as reciprocal adaptation. In addition, some studies have revealed a role for host genetics in the development of illness, including possible Mendelian inheritance patterns for dermatophytosis tendency. This paper emphasizes the complexity of the genetic link between dermatophytes and their natural and accidental hosts. According to a literature study, different ideas and methodologies may lead to different interpretations of this connection. Selecting an appropriate model for analysis and reasoning is a critical step in better understanding these disorders. A significant portion of the research is focused on the host's genetic and immunological response to dermatophyte infection. Future studies will require a broader exploration of the dermatophyte genome in combination with analysis of large phenotypically well-characterized populations of various dermatophyte species in order to identify the main factors mediating infection risk that can be targeted to disrupt host–pathogen interactions and used in therapies. As a result, both conceptually and practically, extensive study on the interactions between dermatophytes and their specific hosts, which comprise intricate molecular pathways, is critical. However, it is undeniable that genetic predisposition plays a crucial role in the susceptibility to dermatophyte infection.