lncRNAs are upregulated and downregulated in OS cells. Angiogenesis, metastasis, cell signaling, autophagy, and death

Abstract

Many lncRNAs are elevated and downregulated in osteosarcoma (OS) cells. These RNAs are involved in a variety of biological processes, including angiogenesis, metastasis, cell signaling, autophagia, and death. In this paper, we give a concise rundown of the lncRNAs that are abnormally expressed in CDDP-resistant OS cell lines. The manipulation of influx/efflux transporters, apoptosis escape, interference in DNA repair mechanisms, autophagy triggered by therapy, and the control of cell signaling pathways appear to be essential mechanisms implicated in the chemoresistance of CDDP mediated by lncRNAs. Overexpression of LNC-ROR, OIP5-AS1, NCK-AS1, and NORAD increases drug efflux transporter activity, whereas overexpression of ANRIL and DNAJC3-AS1 and downregulation of NEAT1, LINC00161, and LINC00473 lowers apoptotic activation. Furthermore, elevated levels of SNHG16 are linked to autophagy induction, whereas overexpression of MIR17HG, TTN-AS1, and KCNQ1OT1 is linked to DNA damage repair and cell cycle dysregulation. Finally, Wnt/-catenin modulation is linked to overexpression of MSC-AS1, TUG1, HOTTIP, and OIP5-AS1, and PI3K/AKT promotes OS cancer cell chemoresistance. When taken together, these findings are expected to lead to a better understanding of CDDP chemoresistance in OS patients as well as improved therapeutic options.