Many miRNAs participate in inflammatory regulation and bone metabolism. Overexpression of miR21 and miR155 releases proinflammatory cytokines

Abstract

A variety of miRNAs involved in inflammatory regulation and bone metabolism impact the clinical course of periodontitis and periimplantitis. The expression levels of the miR146 family, the let7 family, and miR1445p are all raised in periodontal lesions, resulting in accelerated tissue deterioration via the TLR, NFB, and other signaling pathways. Overexpression of miR21 and miR155 induces the release of proinflammatory cytokines. The lack of MiR21 induces significant periodontal bone loss, although cutting down miR155 reduces TNF-induced osteogenesis inhibition to some extent. MiR223, miR27a, and miR128 are all associated with bone remodeling. In periimplantitis, the expression of miR27a and miR128 is downregulated, which might be connected to alveolar bone resorption. To far, only a few studies have been conducted on inflammatory alveolar bone defects and related microRNAs. It is vital to conduct in-depth research to shed light on the possible links between inflammatory alveolar bone defects and miRNAs in order to develop creative strategies to prevent and cure inflammatory alveolar bone defects.