Omics should be integrated with genomics to uncover molecular networks and tissue and single-cell epigenetic changes. With these findings, targeted Pseudoexfoliation syndrome and glaucoma gene therapy procedures may be viable

Abstract

Both these 'omics' approaches, such as transcriptomics, proteomics, metabolomics, and epigenomics, should be combined with genomics to reveal molecular networks and epigenetic alterations at the tissue and single-cell levels, as genomics alone can not provide all answers to the complexity of ocular diseases. With these findings, novel targeted therapy strategies for Pseudoexfoliation (PEX) syndrome and glaucoma may be viable.